com.gnomancerPublished by gnomancer.comv0.5.1Updated Nov 7, 2026
Local raw DNA analysis: haplogroups, traits, ClinVar, pharmacogenomics. Nothing is uploaded.
gnomancer's local MCP server, published by gnomancer.com; no sign-in required; STDIO; 10 tools.
No AI overview yet: these facts come from the registry entry and the server itself.
Desktop only via STDIO. STDIO servers start a local process, so they need the SourceWeft desktop host.
Follow the launch instructions in the repository.
[gnomancer: your DNA, decoded on your own machine]
gnomancer.com · get your raw data · install · PyPI · MCP Registry · Discord
Take the raw file you already downloaded from AncestryDNA, 23andMe, MyHeritage, FamilyTreeDNA or LivingDNA (or a VCF) and turn it into one readable report. Everything runs on your computer. Nothing is uploaded.
Open AncestryDNA_analysis/REPORT.html. No Python? curl -fsSL https://gnomancer.com/install.sh | bash sets everything up (macOS and Linux; Windows via WSL).
gnomancer family dad.zip mom.zip me.zip shows shared DNA and the likely relationship for each pair, which lines you share, and which parent each of your alleles came from.gnomancer watch re-checks ClinVar each month and tells you only what was reclassified at sites you carry.gnomancer is also an MCP server. Connect it and ask "what does my report say about caffeine?"
Only derived results reach the assistant, never the raw file, and the health tables are separate tools fetched only on request. The repo also works as a Claude plugin (skills/gnomancer/SKILL.md).
Your genotype file never leaves your machine. The only network traffic is the one-time download of public tools and references. The optional --ai flag sends the structured results (not the file) to the Anthropic API to write the narrative, and only when you ask.
A genotyping array reads about 0.02% of the genome at pre-chosen sites, and its calls at rare sites are wrong often enough that a clinical lab found 40% did not confirm. gnomancer tells you what the chip says and how far to trust it. Confirm anything that matters with a clinical-grade test and a clinician or genetic counselor.
Discord community · CLI options · vendors and quirks · the marker panel · tools under the hood · development · MCP registry · contributing
MIT licensed. The tools it downloads keep their own licenses; see NOTICE.md for credits.
mcp-name: com.gnomancer/gnomancer
Source: README.md at commit 0d17940
Run gnomancer on a raw DNA file (AncestryDNA, 23andMe, MyHeritage, FamilyTreeDNA, LivingDNA, VCF; .zip OK). Takes one to three minutes; the very first run also downloads ~250 MB of open-source tools and references (a few minutes), automatically. fast=True skips Yleaf, ClinVar and PharmCAT. Returns the output directory, report paths and the at-a-glance digest. The file never leaves this machine.
fastpathrequiredout_dirancestryHeadline results of the current (or given) report: quality, lineages, ancestry estimate, multi-site readings and the at-a-glance digest. No health tables; use clinvar_findings / pharmacogenomics for those.
report_dirReturn one section of REPORT.md by (partial, case-insensitive) heading, e.g. 'Paternal', 'Marker panel', 'PharmCAT'. With no name, lists the available section headings.
namereport_dirGenotype and reading for one rsID. Uses the curated panel when the site is in it; otherwise reads the single site from the user's raw file (nothing else is read or returned). Says so if the chip did not type the site.
rsidrequiredreport_dirClinVar scan results (pathogenic / likely-pathogenic alleles carried, with plausibility confidence and flags). Health-sensitive: call only when the user asks about disease risk or carrier status.
report_dirPharmCAT star-allele diplotypes and phenotypes per gene, with coverage. Provisional: untyped positions are assumed reference. Call when the user asks about medications or drug metabolism.
report_dirRe-check ClinVar for this report: downloads a new ClinVar release if NCBI published one, rescans the user's sites and reports only classification changes (newly pathogenic, downgraded, review-status changes). The first run writes a baseline. Health-sensitive: run when the user asks.
forcereport_dirCompare two or more relatives' raw DNA files: shared DNA per pair with a relationship estimate, shared maternal/ paternal lines, side-by-side panel genotypes and, for parent-parent-child sets, which parent each allele came from plus a Mendelian-consistency check. Runs locally. Returns the pair table and report paths.
namespathsrequiredout_dirhaplogroupsThe prompt for writing the plain-language narrative that goes at the top of the report. Follow it exactly, then pass your text to set_narrative.
report_dirEmbed a narrative summary (yours, written from narrative_prompt) at the top of the report. Saves summary.md and regenerates REPORT.html / REPORT.md with the same options as the original run.
textrequiredreport_dir90% of the applicable checks met
How complete this listing is, computed from the registry entry, the endpoint and public sources. Not a rating of the server and not a statement that it is safe or working today: reachability is a dated check, and no installs or reviews go into the score.
Declare the credential headers in the registry entry, or keep the endpoint answering the probe so its auth can be classified.
pipx install gnomancer # Python 3.10+; Java 17+ for the mtDNA haplogroup and PharmCAT stepsgnomancer ~/Downloads/AncestryDNA.zip # first run fetches the open-source tools and references once (~250 MB)claude mcp add gnomancer -- uvx gnomancer serve # Claude Code; Claude Desktop/Cursor: command "uvx", args ["gnomancer","serve"]