Aria Mcp Server

io.github.pkotecha-engPublished by GitHub account pkotecha-engv0.2.1Updated Oct 24, 2026

Search 35M+ PubMed, 400K+ ClinicalTrials.gov & ISRCTN trials. Prompts included. No API key.

VerifiedSTDIODesktop onlyWeb Search & ScrapingKnowledge & Memory

Overview

AI-generated overview

A local MCP server that lets an assistant search PubMed literature and ClinicalTrials.gov and ISRCTN clinical trial registries, with no API key needed.

What you can do
Search biomedical literature across 35M+ peer-reviewed papers via PubMed/NCBI E-utilities and retrieve results for a topic or drug query. Search clinical trials on ClinicalTrials.gov and UK/European trials on ISRCTN, including recruiting status. Run built-in prompts that assemble an evidence and trial brief for a condition, a structured adverse-event and safety profile for a drug, or a patient eligibility assessment across recruiting trials. Read reference resources on trial phases and FDA designations, high-impact journals by specialty, and FDA databases for drug and regulatory research.
When to use it
Useful for life sciences research, clinical trial coordination, and drug discovery work where an assistant should ground answers in published literature and active trial listings rather than general knowledge. Also handy for quick cross-checks of published evidence against recruiting trials for a condition.
Requirements
Runs as a local process installed from the PyPI package aria-mcp-server, requiring Python 3.12 or newer; start it with the aria-mcp-server command and register it in the client's MCP configuration. It needs outbound network access to the public PubMed, ClinicalTrials.gov and ISRCTN APIs. No API keys or environment variables are declared.
Before you install
Queries and search terms are sent to the public NCBI, ClinicalTrials.gov and ISRCTN APIs, so treat anything you search as leaving your machine. Results are registry and literature data only and should be verified before clinical or regulatory use; the eligibility prompt is an assessment aid, not medical advice.

Installation

In SourceWeft

  1. Open Aria Mcp Server in the dashboard and add it to a workspace.
  2. Enable the server for the chats that should use its tools.

Desktop only via STDIO. STDIO servers start a local process, so they need the SourceWeft desktop host.

Other MCP clients

Follow the launch instructions in the repository.

README

🧬 ARIA Clinical Research MCP Server

A standalone MCP server that gives any Claude agent real-time access to biomedical literature and clinical trials — no API keys required. [aria-mcp-server MCP server]

Tools

ToolDescription
search_pubmedSearch 35M+ peer-reviewed papers via NCBI E-utilities
search_clinical_trialsSearch 400K+ trials via ClinicalTrials.gov v2 API
search_isrctnSearch UK/European trials via ISRCTN registry

Prompts

PromptDescription
clinical-research-briefComprehensive evidence + trial brief for a condition
adverse-event-analysisStructured AE and safety profile for a drug
trial-eligibility-checkerPatient eligibility assessment across recruiting trials

Resources

ResourceDescription
info://ariaOverview of ARIA capabilities and data sources
reference://trial-phasesPhase I–IV definitions and FDA special designations
reference://high-impact-journalsCurated high-impact journals by specialty
reference://fda-databasesFDA databases for drug, safety, and regulatory research

Example queries

Once connected, ask Claude:

  • "Search PubMed for ketogenic diet pediatric epilepsy outcomes"
  • "Find recruiting trials for lung cancer immunotherapy"
  • "What does the literature say about veliparib in ovarian cancer, and are there active trials?"
  • "Find UK and European trials for pediatric epilepsy via ISRCTN"

Quickstart

bash
pip install aria-mcp-serveraria-mcp-server

Connect to Claude Desktop

Add to ~/Library/Application Support/Claude/claude_desktop_config.json:

json
{  "mcpServers": {    "aria-clinical-research": {      "command": "aria-mcp-server"    }  }}

Restart Claude Desktop. The server will appear under Settings → Developer → Local MCP Servers.

Data sources

  • PubMed — NCBI E-utilities (public API, no key required)
  • ClinicalTrials.gov — v2 REST API (public API, no key required)
  • ISRCTN — UK/European clinical trials registry (public API, no key required)

Tech stack

  • FastMCP — MCP server framework
  • Python 3.12+

Use cases

  • Life sciences researchers needing real-time literature access
  • Clinical trial coordinators checking eligibility and recruiting status
  • Drug discovery teams cross-referencing published evidence with active trials
  • Any Claude agent needing grounded biomedical knowledge

Project Structure

aria-mcp-server/          ← root, where mcp-publisher runs├── aria_mcp_server/      ← Python package│   ├── __init__.py│   ├── server.py│   └── tools.py├── server.json           ← MCP registry metadata├── pyproject.toml├── README.md├── LICENSE└── glama.json

Built by

Pooja Kotecha · dinq.me/pkotecha-eng

Source: README.md at commit 5624b7c

Tools

0
SourceWeft has not started this package in its sandbox yet, so its tools are not known.

Version history

1
  1. v0.2.1LatestSep 16, 2026

Score

50% of the applicable checks met

How complete this listing is, computed from the registry entry, the endpoint and public sources. Not a rating of the server and not a statement that it is safe or working today: reachability is a dated check, and no installs or reviews go into the score.

  • Reached in the last 30 days25 pts

    Keep the endpoint answering the MCP handshake; SourceWeft probes it every 30 days.

  • Auth declared10 pts

    Declare the credential headers in the registry entry, or keep the endpoint answering the probe so its auth can be classified.

  • Tools listed15 pts

    Answer tools/list without a credential, or ship a package that starts in a sandbox without one.

  • DescriptionRequired15 pts
  • Logo10 pts
  • Documentation15 pts
  • License10 pts